Leinster take on Zebre in Sunday's RaboDirect Pro12 clash having won six of their last seven away fixtures in all tournaments.
The Leinstermen have not lost to an Italian opponent since they visited Treviso in September 2010 but Zebre are attempting to win back-to-back matches for the first time having beaten Treviso last time out.
With 13 players named in the Ireland squad to face Wales in the Six Nations, Leinster coach Matt O'Connor has made a number of changes to his starting XV from the team that took to the field against Connacht.
Academy players Sam Coghlan-Murray and Tadhg Furlong get a chance on the left wing and at tight head respectively, while three other Leinster Academy players are named amongst the replacements.
Experienced duo of Mike McCarthy and Jordi Murphy are also named in the starting XV.
In the day's other game, Glasgow tackle Connacht at Scotstoun having won three of their last four home games against Irish provinces.
Glasgow Warriors boss Gregor Townsend has handed first starts to wingers Lee Jones and Rory Hughes.
Jones arrived this week on loan until the end of the season, having been released to the club from Scotland Sevens duty in New Zealand.
Hughes joined the club in the summer of 2013 as part of the Elite Development Programme and has been on good form for Stirling County in the Premiership.
Richie Vernon starts his first game at centre, since switching positions from the back row, and will partner Mark Bennett in midfield.
Connacht head coach Pat Lam has named 21-year-old fly-half Jack Carty in his starting XV.
Carty will play alongside scrum-half Kieran Marmion while Craig Ronaldson returns from injury to partner Galway-born Eoin Griffin in the centres.
Fionn Carr starts on the right wing for his 100th league game while Connacht's joint top try scorer of the season (with Marmion) Matt Healy is named on the left.
The Dragons' game with Edinburgh at Rodney Parade has been postponed because of a waterlogged pitch.