Leinster recorded back-to-back league victories for the first time this term with a 33-8 win over Edinburgh at the RDS .
Table-toppers Ospreys host Connacht on Friday looking to make it seven wins on the bounce in the Guinness PRO12.
London Irish made it two wins from two in the Challenge Cup as they battled past Grenoble 25-15 in France.
Friday sees five games in Round 2 of the newly-formed European Rugby Challenge Cup, including Dragons against Newcastle.
Edinburgh began their Challenge Cup campaign with a 15-13 win at Bordeaux while Newcastle Falcons toppled Bucharest.
Newcastle host Bucharest Wolves in the European Rugby Challenge Cup on Friday, while Edinburgh visit Begles-Bordeaux.
Edinburgh back-row Cornell Du Preez has undergone surgery after suffering a broken ankle in Saturday’s win over Dragons.
Tom Heathcote kicked 14 points as Edinburgh beat fellow strugglers Newport Gwent Dragons 24-10.
The Manchester derby live only on Sky Sports
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