Harlequins withstood a second-half comeback from Sale Sharks to win 25-23 at the AJ Bell Stadium.
Sale Sharks face Harlequins at the AJ Bell Stadium on Saturday looking to keep their faint top six hopes alive.
Sale's hopes of qualification for next season's European Champions Cup were dealt a blow as they lost at London Irish.
Steve Diamond could not contain his fury at referee Greg Macdonald after his Sale Sharks side lost at London Irish.
London Irish host Sale on Sunday seeking back-to-back Aviva Premiership wins for the first time since February 2014.
Sale recorded a highly-important 23-6 Aviva Premiership win over Gloucester at the AJ Bell Stadium on Sunday.
Mark Cueto will make his 300th appearance for Sale Sharks in Sunday’s Aviva Premiership clash with Gloucester.
Aviva Premiership side Sale Sharks have announced that coach Bryan Redpath has parted company with the club.
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