Quintin Geldenhuys will captain Italy on their summer tour which takes in Tests with Fiji, Samoa and Japan.
England know that their Six Nations fate will not be in their own hands even if they register a big win against Italy.
Danielle Waterman returned from injury to score a try as England's women beat Italy 24-0 in Rovato.
Paul O'Connell expecting Ireland to improve on their performances in the Test wins against Argentina
Sergio Parisse returns from injury to lead Italy into Saturday's Six Nations game against England in Rome.
Mako Vunipola will start at loosehead prop for England in Saturday's Six Nations match against Italy.
Sign up to the weekly E-Maul for all the latest news, features and videos
This season, more of the games that matter are live on Sky Sports.
We've a host of top class rugby union action this season.
Predict six scores to win the £250,000 jackpot prize
The world of sport in 15 minutes EVERY 15 minutes.