Harlequins star Nick Evans is confident of retaining momentum despite losing several senior players to Six Nations duty.
Harlequins forward Will Collier has been ruled out for the rest of the season with a ruptured cruciate ligament.
Harlequins fought for a Champions Cup quarter-final place with a 47-19 win at Castres, but their efforts were in vein.
Conor O'Shea insists the agony of Harlequins' Champions Cup exit will spur them on for the rest of the season.
England head coach Stuart Lancaster is set to name Sale fly-half Danny Cipriani in Six Nations squad.
A first-half brace of tries against the run of play helped Wasps to a superb 23-3 Champions Cup win over Harlequins at the Stoop on Saturday.
Wasps boss Dai Young was full of praise for captain James Haskell after the victory at Harlequins.
Karl Dickson has signed a contract extension that will keep him at Harlequins until the end of the 2016/17 season.
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