Kyle Sinckler will miss Harlequins' clash against London Irish at the weekend after being handed a one-week ban.
Northampton beat Harlequins 17-13 at Franklin's Gardens to move 13 points clear at the top of the Aviva Premiership.
Harlequins have signed Fiji back-row Natani Talei until the end of the season.
Henry Slade contributed 27 points as Exeter beat Harlequins 32-21 in their Premiership encounter at the Stoop.
A sold out Twickenham Stoop awaits Harlequins as they make two changes for their Aviva Premiership clash with Exeter.
Harlequins have confirmed wing Charlie Walker has signed a new two-year contract at The Stoop.
Wasps director of rugby Dai Young was thrilled with his side after they romped to a 37-6 Aviva Premiership victory over Harlequins.
Harlequins have signed prop Matt Shields on a permanent basis until the end of the 2015-16 season.
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