Sale Sharks secured their first Premiership win at the Stoop in more than six years with a 16-12 triumph over Harlequins.
Sale Sharks boss Steve Diamond praised his players after they claimed a rare away win at Harlequins on Friday night.
Harlequins take on fellow mid-table side Sale in Friday's Aviva Premiership clash while Newcastle host Gloucester.
David Humphreys insists Gloucester had the blessing of Wales to field Richard Hibbard in the Premiership on Friday.
Richard Hibbard's late cameo appearance couldn't spare Gloucester from going down to a 22-15 defeat at home to Harlequins.
The return of the Aviva Premiership following a month of cup fixtures kicks off with two Friday fixtures.
Coaches Mark Mapletoft and Tony Diprose have both signed new contracts with Harlequins.
Harlequins came from 21-8 down to beat Newport Gwent Dragons 31-21 in their LV= Cup clash at the Stoop.
More of the games that matter on Sky Sports
Don’t miss the Autumn Internationals
For all the latest news, features and videos
We've a host of top class rugby union action
Predict six scores to win the £250,000 jackpot!