Exeter Chiefs begin their LV= Cup title defence on Saturday, while Saracens lock horns with Harlequins on Sunday.
Sharks fly-half Tim Swiel is to join Harlequins on loan until February 2015 as cover for the injured Ben Botica.
Northampton Saints lock Christian Day has been appointed chairman of the Rugby Players’ Association.
Harlequins beat local rivals Wasps 23-16 at Adams Park to go joint top of Pool 2 of the European Champions Cup.
Toulon's European Cup victory over Ulster proves they're the team to beat once again, says Stuart Barnes.
Harlequins director of rugby Conor O'Shea was in buoyant mood after his side secured a deserved 23-16 win over Wasps.
In the lone all-Premiership showdown of the weekend, Wasps host Harlequins at Adams Park (kick-off 5.15pm).
Jonny Wilkinson, Will Greenwood and Nick Easter analyse all the action from the opening weekend.
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