Clermont coach Frank Azema has made wholesale changes to his pack for his side's Top 14 encounter against Castres.
Wasps played their final match in High Wycombe, and the London outfit signed off in style with a 44-17 win over Castres.
Wasps aim keep their slender hopes of quarter-final qualification alive with a second victory over Castres.
Castres Olympique host Wasps in the European Rugby Champions Cup on Sunday, live on Sky Sports.
Reigning Top 14 champions Toulon claimed a 27-19 victory against Clermont Auvergne in a clash of the titans on Saturday.
Ireland's joy, England's misery and Wales' woe... Rupert Cox looks at the week in rugby union.
A depleted Toulon team came a cropper at Castres, allowing Clermont Auvergne to take over as new leaders in the Top 14.
The final of the Top 14 will be held at Barcelona’s Nou Camp at the end of the 2015-16 season.
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