Bottom side Worcester go in search of their first Aviva Premiership victory of the season on Friday night when they play host to Bath at Sixways.
Argentina flanker Leonardo Senatore is handed a Warriors debut along with Paul Warwick, who makes his first league start in place of Ignacio Mieres.
Chris Jones returns to the second-row and will partner Argentinian international Mariano Galarza, while Ofa Fainga'anuku will feature alongside Agustin Creevy and Euan Murray in the front-row.
John Andress, George Porter, Sam Betty and Ravai Fatiaki return to the squad as Warriors prepare to tackle one of the league's form sides.
Bath, meanwhile, have made just one enforced change to the side that beat Gloucester last weekend with academy lock Will Spencer coming into the second-row alongside Stuart Hooper, replacing Dave Attwood who has been named on the bench for England.
Elsewhere in the pack, the all-international front-row of Paul James, Rob Webber and Anthony Perenise pack down with Matt Garvey, Francois Louw and Carl Fearns providing power in the back-row.
Sharks v Chiefs
Exeter Chiefs boss Rob Baxter has made just the one change for the game against the Sale Sharks at the AJ Bell Stadium - with Welshman Tom James returning to place Tongan winger Fetu'u Vainikolo while he's away on international duty.
Luke Arscott is on the bench for his first involvement with the Chiefs this season, after being sidelined since pre-season with a nasty finger injury.
Four wins in six starts this term have put the Chiefs in a healthy position in English rugby's top flight and tomorrow night they will be looking to add the name of Sale Sharks to their list of seasonal scalps claimed.
The Sharks, however, are a different proposition to that of 12 months ago and although they claimed a first-ever top flight win over the Chiefs in the corresponding fixture last season, Baxter is aware his side's latest trip to Manchester will be a formidable challenge.
Sale director of rugby Steve Diamond has made three changes to his run-on side that lost 24-3 to Harlequins at the Stoop last weekend.
All the changes are amongst the forwards with the most significant being captain Dan Braid's return to the openside flank after doing duty on the blindside last week.
Braid comes in for David Seymour - who drops down to the bench - while fellow New Zealander Michael Paterson starts in the number six jersey. The other changes see Kirill Kulemin replacing Jonathan Mills at lock while Vadim Cobilas is preferred to Henry Thomas at tighthead prop.
Mills and Thomas are also included amongst the replacements.