On Friday night, Worcester welcome Harlequins to Sixways as they attempt to win their first Premiership game in eight attempts.
They are rightly 13/8 outsiders to win the game, however it would have been bigger had Harlequins not had such a nervy opener against London Wasps and the narrow defeat to, much-fancied, Northampton last week.
With a minus five handicap, the Quins are only marginal favourites, yet they have beaten the Warriors in 13 of the 16 matches between the two.
As it's only round three of the 2013/14 campaign, much can still be drawn from last year and the home side lost their last five games, including a 42-26 at tonight's venue against the Quins.
With the Warriors having not beaten the men from the Stoop since 2005, all fingers point to a Harlequins win and, if the visitors are serious about contending for honours this year, they will need to put in a good performance on Friday night.
Friday's other game sees London Wasps make the trip to Salford to take on Sale Sharks.
The Wasps come into this fixture on the back of two losses in the opening two rounds, yet their points difference reads a mere minus five.
The home side secured a narrow 22-16 in the opening round against Gloucester but came up short last week to newly-promoted Newcastle on their home ground.
As the Wasps are the outsiders this week with a +3 handicap at 10/11, they are the best value of all the round three fixtures.
They are 5/4 to win the game outright and, with Sale Director of Rugby Steve Diamond ringing the changes for Sale, this is not out of the London side's reach.
In what is likely to be a very physical affair, Dai Young's side could have an advantage with Italian hooker Carlo Festuccia in line to make his competitive debut.
The 16 stone forward brings a wealth of experience to the side having made 54 appearances for his national side and, with Andy Goode in good form from the boot, the Wasps will look to rack up the points whenever possible.
View from the Sky Bet trading room...
"We expect team news to play a vital part in this weekend's odds.
"Tom Varndell is missing for the Wasps, yet Sale have made a number of changes to the side which lost to Newcastle last week which could go either way.
" We were tempted to go for scratch on this game but early season form has meant we have made Sale marginal favourites.