There are three games in the RaboDirect Pro12 on Saturday, with leaders Munster in action against Zebre while Cardiff Blues entertain Glasgow and bottom-club Connacht welcome Edinburgh.
Munster are the only side left in the competition with a 100 per cent home winning record this season and they have won all three previous matches they have played against the Italians.
Ireland cap Donnacha Ryan starts at second-row for The Munstermen at Musgrave Park, while Tommy O'Donnell and Felix Jones return from international duty as head coach Rob Penney makes nine changes to the side that beat Cardiff Blues 54-13 last week.
Ian Keatley and Johne Murphy form an exciting new centre partnership with Gerhard van den Heever and Simon Zebo keeping their places in the side after both touched down last weekend. Zebo moves to the left wing with Jones coming in at full-back.
Cathal Sheridan makes his first start since injuring his knee against Ulster in January and partners JJ Hanrahan in the half-backs.
Zebre front-row Tommaso D'Apice is given the nod at hooker alongside Andre De Marchi and Dario Chistollini.
Andries van Schalkwyk skippers the side from the openside flank, while experienced Kiwi and ex-All Black scrum-half Brendon Leonard wears number nine.
Cardiff welcome Blues
Centre Isaia Tuifua will make his full league debut as Cardiff tackle Glasgow at the Arms Park.
The Blues' only victory in their last six Rabo fixtures was at home to the Dragons on New Year's Day.
Samoa international Tuifua, who has featured off the bench in the last two games, is called into the starting line-up and one of seven changes made by boss Phil Davies for the clash with the high-flying Scottish outfit.
Tuifua will line up alongside the fit-again Dafydd Hewitt in midfield, while there is also a recall for Richard Smith on the wing and Simon Humberstone at fly half.
There is also a return of prop Gethin Jenkins, who will captain the team, and back row Sam Warburton for valuable game-time during the Six Nations campaign.
Ed Kalman will make his 100th appearance for Warriors, who have won all six of their games on the road in the Pro12 this season.
Glasgow Warriors head coach Gregor Townsend has selected the same side which started in the win over Connacht on Sunday for the trip to Wales.
After joining the Warriors this week, new signing Folau Niua could make his debut from the bench.
"We travel to Cardiff with plenty of motivation given it was our two defeats to the Blues that effectively ended our Heineken Cup ambitions this season," said Townsend.
Edinburgh boss Alan Solomons has named an unchanged line-up for the visit to Connacht at the Sportsground.
The visitors head into the clash having won just one of their last twelve Pro12 matches while the hosts will be playing in the tournament for the first time since Boxing Day.
Andries Strauss, Mike Coman, Carl Bezuidenhout and James Hilterbrand should all make their debuts in Galway.
The only changes to the squad named last week appear on the bench, where Scotland front-row forwards Ross Ford and Geoff Cross return from international duty to replace elite development duo George Turner and Ewan McQuillin.
Meanwhile, Connacht head coach Pat Lam has made three personnel changes to the team that lined up against Glasgow last weekend.
Following his start in last week's Eagles game, Dave McSharry makes a welcome Pro12 return to partner Eoin Griffin in the centre. His appearance allows Craig Ronaldson to shift to fly-half where he forms the half-back pairing with Kieran Marmion.
Galway-born Tiernan O'Halloran has been named to start on the left wing and features in an all-Irish qualified back line.
Up front, Connacht's highest capped player Michael Swift is brought into the second-row. His introduction means that Andrew Browne moves back to openside flanker.
Number eight John Muldoon will captain the side at the Sportsground.