England Women's coach Gary Street has rung the changes for Sunday's Six Nations meeting with Scotland at Aberdeen Grammar.
Only five players are retained from last weekend's 18-6 defeat to France - skipper Katy Mclean, Rachael Burford, Emily Scarratt, Sarah Hunter and Marlie Packer.
Mercedes Foy and Sasha Acheson could be set to make their Six Nations debuts as they are named on the bench, while Joanne McGilchrist returns to international action for the first time this season.
"After a thoroughly disappointing opener to France, it is vital that we bounce back against Scotland and get our Six Nations campaign back on track," said Street.
"There are lots of changes to this team but I was always planning on using the majority of our World Cup training squad over the first two games.
"This is a chance for all the players to put their hands up for the game against Ireland at Twickenham on February 22.
"We've had a good hard look at the game and we are certainly looking to improve in all areas on Sunday but especially around the breakdown. We know we can and will improve, and we have got a big point to prove on Sunday.
"We know Scotland will be up for it at home and need to come out firing. We will not lack any motivation for the game.
"I want to get our season back on track and show the quality we know we have."
England: Scarratt, Thompson, Reed, Burford, Allan, McLean (c), Mason; Purdy, Fleetwood, Keates, Essex, McGilchrist, Gallagher, Packer, Hunter
Replacements: Foy, Hemming, Acheson, Braund, Alphonsi, Gulliver, Large, Wilson