Keith Gillespie and Jonny Evans have been forced out of Northern Ireland's Euro 2008 qualifier with Sweden next week.
The influential duo have failed to shake off knocks and they have both been ruled out of Nigel Worthington's squad.
Sheffield United winger Gillespie is struggling with a hamstring injury and he has stayed at Bramall Lane to undergo treatment on the problem.
Manchester United starlet Evans has been ruled out with an ankle injury.
Worthington has drafted in Ross County's Sean Webb, who is currently on loan at Accrington Stanley, and Glentoran striker Gary Hamilton as replacements for the injured duo.
The news is a major blow for Worthington who is already without the likes of Chris Baird, Warren Feeney, Damien Johnson and Michael Duff for the game in Stockholm next Wednesday.