San Marino claimed the first European Championship qualifying point in their history after a stalemate with Estonia.
Slovakia registered their second win in four days with a 3-1 European Championship qualifying victory over Belarus.
Paco Alcacer will be hoping to play an important part when Spain travel to European Qualifying Group C leaders Slovakia.
Spain took the first steps on the road to recovery from their World Cup woe with a 5-1 win over Macedonia in Valencia.
Substitute Alexander Kerzhakov scored a late winner as Russia overcame Slovakia 1-0 in St Petersburg.
UEFA have approved the launch of a Nations League from 2018, with the new tournament to be played every second year.