Alvaro Morata scored as Spain beat Ukraine 1-0 in Friday's European Qualifiers, while Slovakia won to stay top of Group C.
San Marino claimed the first European Championship qualifying point in their history after a stalemate with Estonia.
Slovakia registered their second win in four days with a 3-1 European Championship qualifying victory over Belarus.
Paco Alcacer will be hoping to play an important part when Spain travel to European Qualifying Group C leaders Slovakia.
Find out more about Sky Sports' live coverage of 250 European Qualifiers this season.
Spain took the first steps on the road to recovery from their World Cup woe with a 5-1 win over Macedonia in Valencia.