World champions Germany beat European champions Spain 1-0 in Vigo on Tuesday night thanks to a late goal from Toni Kroos.
Spain stayed in touch with Group C leaders Slovakia after a comfortable 3-0 win over Belarus in Huelva.
Isco's strike for Spain against Belarus in Huelva was voted Goal of the Night by followers of @SkyFootball on Twitter on Saturday.
Manchester United goalkeeper David de Gea has dislocated a finger in training while on international duty with Spain.
Midfielder Koke has urged Spain to work hard and "step up" in their efforts, starting against Belarus on Saturday.
Villarreal captain Bruno Soriano has spoken of his delight at his return to the Spain squad after a prolonged absence from the international scene.
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