Manchester United striker Javier Hernandez has been taken to hospital with a suspected broken collarbone.
Chile thrashed Bolivia 5-0 at the Copa America while Ecuador beat Mexico 2-1 for their first finals win in 11 years.
Copa America hosts Chile had two goals ruled out for offside in a roller coaster 3-3 draw against Mexico in Santiago.
Mexico made an underwhelming start to their Copa America campaign as they were held to a goalless draw by Bolivia.
Germany beat European champions Spain 1-0 in Tuesday night's friendly thanks to a late goal from Toni Kroos.
Divock Origi and Romelu Lukaku helped Belgium beat Iceland 3-1, while Carlos Vela inspired Mexico to beat Netherlands.