Vitesse returned to the top of the Eredivisie with a 3-0 win over Cambuur Leeuwarden, while PSV Eindhoven lost 3-1 against Feyenoord in Sunday's action.
The victory extended the Arnhem-based club's winning run to five games but Cambuur remain just two points above the relegation zone.
Marko Vejinovic opened the scoring just after the half hour and second-half goals from Kelvin Leerdam and Giorgi Chanturia sealed the win.
Second-placed Ajax sit just two points back following a comfortable 4-0 win against ADO Den Haag.
Davy Klaassen and Viktor Fischer had the defending champions 2-0 up at the break and further goals from Ricardo Van Rhijn and Bojan Krkic completed the rout.
Feyenoord took advantage of AZ Alkmaar's defeat to NEC to move into fourth with a 3-1 win over PSV.
Jean-Paul Boetius scored the opener on the stroke of half time and Graziano Pelle doubled the lead from the penalty spot.
Jeffrey Bruma grabbed one back shortly after but Pelle's second with 25 minutes remaining completed the scoring.
Alireza Jahanbakhsh also bagged a brace as NEC claimed a 3-2 win over AZ.
Marnick Vermijl and Roy Beerens had traded goals before the Iranian grabbed his double and Steven Berghuis grabbed a late second for the visitors.