Stefano Fiore gave Lazio the dream start with the opening goal after just five minutes and Bernardo Corradi added a second 11 minutes later.
Claudio Lopez made sure of the win with the third goal from the penalty spot on 68 minutes as Lazio warmed up their Uefa Cup semi-final with Porto in perfect fashion.
Reggina moved out of the bottom four with a narrow 1-0 win at home to Empoli.
Japanese star Shunsuke Nakamura netted the only goal of the game from the penalty spot on 52 minutes to lift them above Atalanta in the table.
Brescia moved into the top half of the table to ease any fears of relegation with an impressive 3-0 victory over Atalanta.
Stephan Appiah fired Brescia in front on 29 minutes and the visitors' hopes of getting back into the game suffered a blow when Damiano Zenoni was sent off seven minutes later.
Roberto Baggio made the numerical advantage count doubling the lead a minute before the break and Fabio Petruzzi added a third three minutes from time.
Chievo stayed in the hunt for a European spot with a convincing 3-0 win over fellow European hopefuls Udinese.
Sasa Bjelanovic opened the scoring for the home side after just ten minutes and Federico Cossato doubled the lead after 32 minutes.
Chievo wrapped up the win with the third from Sergio Pellisier after 68 minutes.
Perugia were held to a 1-1 draw at home to Bologna.
Greek striker Zivis Vryzas fired Perugia in front on 32 minutes, but veteran striker Guiseppe Signori levelled for the visitors after 66 minutes.
Enzo Maresca's last-minute goal gave Piacenza a priceless 3-3 draw with Modena.
Eusebio Di Francesco gave Piacenza the lead after just eight minutes, but two penalties in two minutes from Omar Milanetto (21,23) turned things on their head for Modena.
Di Francesco netted his second on 64 minutes, before Fabio Vignaroli restored Modena's lead seven minutes from time.
Modena looked set to take all three points until Maresca popped up a minute from time to earn the home side a point.
Click on fixture for full match summary
Brescia v Atalanta
Chievo v Udinese
Internazionale v Roma
Lazio v Como
Perugia v Bologna
Piacenza v Modena
Reggina v Empoli
Click here for updated league table
