Internazionale duo Patrick Vieira and Esteban Cambiasso face a spell on the sidelines through injury.
Vieira is suffering from a knee injury which forced him to miss the midweek draw with Valencia.
Cambiasso sustained a thigh strain against Valencia and was forced to limp off after scoring in the 2-2 draw.
Both players are expected to be missing for a month with their injuries.
It means that the midfield pair will miss the return leg with Valencia in a fortnight's time and the Milan derby next month.