Real Madrid coach Carlo Ancelotti will be looking for ways of channelling his players' anger in the wake of a stunning Clasico which saw them defeated 4-3 on home turf.
With the title race well and truly back on as just one point separates the top three, Madrid have no time to mope about decisions they felt went against them in a match featuring three penalties and a red card for Sergio Ramos.
Cristiano Ronaldo blasted the referees and claimed there was a bias shown against Real Madrid while Ramos, who saw red for the 19th time in his career, also suggested there was an agenda against Madrid.
"If they wanted to balance the league table, they've done it," he said.
Wednesday night sees Madrid travel to fifth-placed Sevilla, and the heat is now on in the stretch run of the season.
Karim Benzema, who scored twice before being sacrificed when Ramos was dismissed, insisted Madrid could remain optimistic about their title chances, pointing to the fixture list with challengers Barcelona and Atletico still to face each other.
"It was a night with a lot of key moments and now we'll try and beat Sevilla," he said. "At this point in the season the matches are all finals and we know that Atletico take on Barcelona on the final day, so we have to think about ourselves in order to win."
The come-from-behind win at the Bernabeu answered Barca's critics as they put themselves right back in the picture.
Lionel Messi was the hat-trick hero on the night, and he is eager to build on the momentum at home to Celta Vigo on Wednesday night.
"It was a very important victory for us," Messi said. "It was a brilliant game for the fans and for us. We can't just stop here though, we have forget about what happened and focus on the future."
While any Clasico steals all the headlines, the result ensured that it was Atletico Madrid who ended the weekend at the top of the table courtesy of their head-to-head record against Real.
On Wednesday, they will look to defend that position at home to a Granada side sat in 11th place, still with work to do to kill off all doubts about relegation as they hover seven points above the drop zone.
The midweek action begins on Tuesday as Malaga seek to pull away from the relegation zone when they host Espanyol before fourth-placed Athletic Bilbao travel to Elche later in the evening.
Two more sides hovering just above the bottom three, Rayo Vallecano and Osasuna, meet in Wednesday's other fixture, hoping to distance themselves from the drop zone before those in it play on Thursday night.
Rock-bottom Real Betis face a tough trip away to Levante, while Almeria take on Valencia at home and Real Valladolid are away to Real Sociedad.
Getafe's match at home to Villarreal completes the fixture list.