Barcelona eased their way into the last-16 of the Copa Del Rey, while Osasuna edged out Malaga to book their progress.
Villarreal, Getafe and Levante are also safely through and remain on course to land major silverware.
Barcelona proved too strong for third tier minnows Cartagena as they prevailed 2-0 on the night and 6-1 on aggregate.
Pedro (31), Cristian Tello (68) and Neymar (88) did the damage for the Catalan giants at the Nou Camp.
An own goal from Weligton inside the opening 60 seconds of a meeting with Osasuna ended up costing Malaga dear.
Eliseu levelled matters just past the hour mark, but a 4-4 draw on aggregate saw Osasuna prevail on away goals.
A solitary strike from Jeremy Perbet (55) was enough to see Villarreal past Elche 3-2 over the course of two tough legs.
Getafe made light work of their meeting with Girona, winning 4-1 on home soil to secure a 5-2 aggregate success.
Pablo Sarabia (2), Adrian Colunga (pen5) and Angel Lafita (34) had the hosts in complete control at the interval and Lisandro Lopez added a fourth on 73 minutes after Alejandro Jandro had pulled one back from the spot (59) for Girona.
Levante headed into a return meeting with Recreativo Huelva knowing they had work to do to overturn a first leg deficit, but ended up surging into the next round with a crushing 4-0 win.
Simao Junior (4), Ruben Garcia (18), Andreas Ivanschitz (50) and Roberto Camarasa (53) were all on target, while a miserable night for Recreativo saw them end the game with 10 men after Alvaro Vega collected two yellow cards.