Marseille's title hopes suffered a major blow as they were beaten 3-1 at Stade Velodrome by outgoing champions Lyon.
Karim Benzema's brace - one of which was from the penalty spot - gave third-placed Lyon, who are unable to retain their crown, a two-goal cushion heading into the second half.
Sylvain Wiltord gave the home side hope 10 minutes from time with his powerful strike which reduced the deficit.
But those dreams of a comeback were soon dashed when Juninho made it 3-1 in stoppage time and the defeat for Marseille leaves them three points adrift of leaders Bordeuax with two games to play.
Rennes grabbed a late equaliser on the road to lowly Nantes who remain second from bottom of the table.
Mamadou Bagayoko opened the scoring for the Ligue 1 strugglers on 41 minutes.
But seven minutes from time Moussa Sow levelled to issue a hammer blow to Nantes who remain in the relegation zone with just two games remaining.
Lille and Nice fought out a 1-1 draw at Stadium Lille earlier in the day.
Anthony Modeste opened the scoring for the visitors with a powerful shot just after the half-hour mark.
Yohan Cabaye brought the scores level with less than 20 minutes to play as the two sides were forced to settle for a point.