Charlton will expect to maintain their place at the peak of the League One table, while struggling Leyton Orient face a difficult task at Huddersfield.
Frontrunners Charlton will fancy their chances of three points to add to their 20 points from eight games, but Chesterfield will be buoyed by their 4-1 win over Carlisle last time out.
Fellow joint leaders Sheffield United face a trip to third-from-bottom Wycombe, while third-placed Huddersfield host struggling Leyton Orient.
Bury are hovering just above the relegation zone and will need a heroic result to remain afloat as they host fourth-placed MK Dons.
Fifth-placed Hartlepool make the long journey to Bournemouth, while Sheffield Wednesday have been hit and miss of late, but Gary Megson's men will be confident at home to Exeter.
Carlisle will hope for an improvement on last week's defeat at home to Stevenage, while Walsall could leapfrog Colchester with a win at the Community Stadium.
Elsewhere, Notts County will hope to add to Rochdale's record of three defeats in four away trips at Meadow Lane, while just two points separate the sides at Boundary Park, where Oldham welcome Brentford.
A win for Tranmere at Deepdale would see them leapfrog Preston and the same applies for Scunthorpe, who are within grasp of Saturday's opponent's Yeovil at Glanford Park.