Sheffield United and Charlton Athletic both will be aiming to maintain their 100 per cent records in League One on Tuesday but will have to get past tricky opponents to do so.
Charlton, once in the Premier League, are away at Colchester United while the Blades host Walsall. Both are level on six points at the top of the table.
Chris Powell's Charlton have defeated Bournemouth and Notts County in their opening two games of the season but will have to take special care of Colchester, who are fourth in the table with four points.
Walsall, too, are expected to provide a stiff test for United as they have collected four points as well.
Tranmere Rovers will hope that both Charlton and United slip up so that they can gain sole control of the pole position. Les Parry's side are third in the standings at the moment but level on points with the top two, and are away at Notts County.
MK Dons have made a promising start to the 2011/12 campaign, having garnered four points from their opening two fixtures. Karl Robinson's side are at Yeovil Town on Tuesday.
Terry Skiverton's team lost 2-0 to Brentford in their opening match and then went down by the same margin to Exeter City in the Carling Cup last week. However, they bounced back with a 3-1 home defeat of Oldham Athletic at the weekend.
Brentford, one of the host of clubs who have collected three points in the division so far, will hope to pick up another win on Tuesday evening when they travel to Exeter, who are third from bottom with just a solitary point.
Bury, who also have just a point from their opening two matches, have had mixed fortunes in the past week. They defeated Coventry City 3-1 at home in the Carling Cup in midweek but suffered a 2-0 loss to Carlisle United in the league in front of their own supporters on Saturday.
On Tuesday, Richie Barker's side welcome Sheffield Wednesday to Gigg Lane.
League One's bottom two clubs Oldham and Leyton Orient will be hoping to pick up their first points against Scunthorpe United and Wycombe Wanderers respectively. Oldham have conceded three goals already, while Orient are yet to score.
Rochdale, who have also struggled in the beginning of the season and have collected just a point, host Carlisle, who won against Bury at the weekend.
Chesterfield and Preston North End, 18th and 19th respectively, confront each other at the B2net Stadium. Both teams have been disappointing in the first couple of weeks of the season, having managed only a point each.
Huddersfield Town, who failed to get past the League One play-off final at the end of last season, have resumed life in the division on the slow.
With two draws in two matches, Lee Clark's side will aim for a win on Tuesday when they take on Hartlepool away from home.
Bournemouth will aspire to make it two league wins in a row as they entertain Stevenage, who have yet to win in three competitive games this month.