Championship leaders Blackpool travel to Barnsley on Saturday, while Peterborough take on Burnley in a bottom-of-the-table clash.
Seagulls and Owls could fly to top on Friday
Championship leaders Blackpool travel to Barnsley on Saturday, while Peterborough take on Burnley in a bottom-of-the-table clash.
But ahead of the Saturday games,
Brighton or
Sheffield Wednesday could go to the top of the table when the sides clash at the Amex Stadium on Friday night.
Gus Poyet's Seagulls sit fourth in the early table with seven points from their opening four games, the same tally as the sixth-placed Owls and a win would take either top.
In Friday's other game, last season's League One champions
Charlton take on local rivals
Crystal Palace in a clash being shown live on
Sky Sports 1HD at 7.45pm.
The Eagles lost their first three games but bounced back to beat the Owls last time, while the Addicks will be looking to earn their second win of the campaign.
Bounce back
In Saturday's action, current leaders
Blackpool travel to
Barnsley looking to bounce back from a 1-0 loss at Leicester last time, while the Tykes will be aiming to maintain their 100 per cent home record.
Second-placed
Blackburn put their unbeaten away record on the line at
Bristol City, who have won both of their games at home this term.
Unbeaten
Nottingham Forest sit third in the early table and next up for Sean O'Driscoll's side is the visit of lowly
Birmingham, who are yet to earn a point away from home.
Fifth-placed
Hull City will be looking to make it three wins on the bounce at home against
Millwall, who have started solidly with two victories so far.
Cardiff and
Leeds sit just outside the play-off berths with seven points apiece and it is sure to prove a hotly-contested affair in Wales.
Slight favourites
The Bluebirds would seem to be slight favourites having won both their home games so far this term, but Leeds boss Neil Warnock will demand a full effort from the Whites.
Middlesbrough put their 100 per cent home record on the line against
Ipswich at The Riverside, while
Huddersfield aim to stay unbeaten at home to
Derby, with both sides locked on five points from their opening four games.
Down at the bottom, Darren Ferguson's
Peterborough travel to third-from-bottom
Burnley looking to pick up their first points of the campaign.
Bolton hover just two places - and one point - above the early drop zone and next up for Owen Coyle's side is the visit of
Watford, who sit in mid-table after two wins from their opening four games.
In Sunday's game,
Wolves host
Leicester in a clash of sides with Premier League aspirations, which is being shown live on
Sky Sports 1HD at 1.15pm.