Martin O'Neill fears Gabriel Agbonlahor will miss Aston Villa's game with Newcastle United at the weekend.
Agbonlahor suffered a hamstring injury in Sunday's defeat at Fulham, which forced him to withdraw from the England squad.
In addition to missing the international friendly with Switzerland, the lively attacker also seems likely to sit out his club's next match against Newcastle.
"We've done a scan and it shows something, which is disappointing," said Villa boss O'Neill. "Gabby has missed out with England and he's a doubt for Saturday.
"It's a setback that he might miss a game for us because he has been absolutely fantastic this season and showed no sign of what people call the 'second season syndrome'.
"His form meant he was on the threshold of things with his country. That time will return for him, I'm sure. It's just a setback for him for now."
But while Agbonlahor is not expected to face the Magpies, team-mate Curtis Davies is optimistic of being fit.
Davies picked up a knee injury at Fulham, although the centre-half admits it is not a serious problem.
"It is a slight knock and I'm getting treatment," said Davies. "I'm hoping to be back training again on Thursday. It's a niggle rather than an injury.
"I'm hoping to play against Newcastle but, as always, that's down to the gaffer."