Manchester City will face Manchester United in the last four of the Carling Cup, while Blackburn take on Aston Villa.
Old Trafford staged a sensational Manchester derby in the Premier League earlier this season, with Michael Owen sealing a 4-3 victory for United deep into stoppage time.
The two sides will now lock horns over two legs in January after being paired together in the draw for the semi-finals.
Manchester City, who will be at home for the first leg, booked their place in the next round with an impressive 3-0 victory over Arsenal on Wednesday night.
United knocked Tottenham out of the competition in a repeat of last season's final on Tuesday and Sir Alex Ferguson has insisted he will keep faith with the same players.
Blackburn meet Villa in the other semi-final after causing an upset in the last eight and beating Chelsea on penalties after a 3-3 draw.
Aston Villa overcame Portsmouth 4-2 at Fratton Park in their quarter-final tie
Manchester City v Manchester United
Blackburn v Aston Villa
First legs to be played week commencing 4th January and second legs week commencing 18th January.