British duo Laura Robson and Dan Evans are both in first-round action in the US Open later today, but Andy Murray will have to wait until the last moment to begin the defence of his title in New York.
Murray does not expect to play his first-round match against France's Michael Llodra until Wednesday, potentially putting him at a disadvantage compared to his main title rivals.
Rafael Nadal and Roger Federer play today, with Nadal taking on American Ryan Harrison and Federer meeting Slovenia's Grega Zemlja in the night session on Arthur Ashe.
Robson plays in the first match on Court 17 against Spain's Lourdes Dominguez Lino, who has proved a tricky opponent for the British number one in the past.
The 19-year-old is seeded for the first time at a grand slam at number 30 and has a lot of ranking points to defend after reaching the fourth round last year, but she will not be piling too much pressure on herself.
That is largely because Robson has missed the last three tournaments with a wrist injury and only started practising fully a few days ago.
Robson has played just two matches since reaching the fourth round at Wimbledon, and it is the fighting spirit she showed at the All England Club that she hopes will stand her in good stead here.
She said: "I felt at Wimbledon I wasn't playing my best tennis. I played really well against (Maria) Kirilenko and after that it was some scrappy wins and I just managed to get through.
"That gave me confidence in that I don't necessarily have to be playing my best tennis to get through these matches."
Evans has already exceeded expectations by coming through qualifying to reach the main draw of a grand slam for the first time.
The 23-year-old from Birmingham, who has won 11 of his last 13 matches, faces Japanese 11th seed Kei Nishikori, with the pair first up on Court 13 at Flushing Meadows.