Andy Murray's price to win Wimbledon has drifted from 11/4 to 100/30 after the Scot was handed a difficult route to the final following Friday's draw.
The world number two opens up his assault on Monday against Benjamin Becker, who he beat just last week en route to winning at Queen's, and is 2/7 to beat the German in straight sets.
Murray could potentially meet fellow Brit James Ward in the second round but the going is likely to get tough at the quarter-final stage, where sixth seed Jo-Wilfried Tsonga is expected to be his opponent.
The big-serving Frenchman (22/1) has beaten Murray just once in nine attempts, though, while either two-time former winner Rafael Nadal (4/1) or defending champion Roger Federer (7/1) are likely to await the 26-year-old in the semi-final.
Sky Bet's Ned Brooker said: "The biggest winner of the draw has clearly been the favourite, Novak Djokovic, who has been shortened from 15/8 to 5/4 given his kind route to the final.
"We make Murray the second favourite behind the Serbian, who is 4/1 to beat the Scot in our final forecast market, while we make anyone in the field 4/7 to stop Djokovic from winning his second Wimbledon title."
In the women's event, meanwhile, punters are looking no further than favourite Serena Williams, who is on a dominant run of 33 consecutive wins, at 1/2 to win her sixth title at SW19, with anyone to halt her in her tracks a 6/4 chance.
British number one Laura Robson will have to dump out 10th seed Maria Kirilenko if she is to advance beyond the first round, but the odds are against the 19-year-old, with her Russian opponent 8/13 to progress.
Fellow Brit Heather Watson will fancy her chances against American Madison Keys as she hopes to build on last year's third-round achievement, but the 21-year-old is a 1000/1 outsider in the outright market.