There was a big upset at the Open Sud de France when veteran Marc Gicquel dumped out second seed Gilles Simon.
In their first match for six years, the two Frenchmen dropped serve twice in the opening set before Gicquel took the tie-breaker 7-4.
But the French No 14 broke twice in the second set to win 7-6 6-3 and book a quarter-final date with sixth seed Jarkko Nieminen in Montpellier.
The Finn advanced with a 7-6 7-6 victory over wildcard Pierre-Hugues Herbert despite the Frenchman's 23 aces.
There was another second round upset when fourth ranked Dmitry Tursunov went down 7-5 6-4 to Denis Istomin of Uzbekistan.
Istomin awaits for Gael Monfils after the fifth seed brushed aside Portugal's Joao Sousa 6-3 6-2, while French qualifier Albano Olivetti downed Russian veteran Nikolay Davydenko 7-6 6-7 7-5.
In the late match top seed Richard Gasquet had few problems overcoming fellow Frenchman Paul-Henri Mathieu 6-1 6-3, making it five home players into the last eight.