Veteran Radek Stepanek will launch the Czech Republic's bid for a first Davis Cup title in 32 years in Prague on Friday.
Stepanek will take on Spain's David Ferrer in the opening match of the 100th Davis Cup final, with Czech No 1 Tomas Berdych facing Nicolas Almagro in the second singles match.
Saturday's doubles match will - nominally - see Ivo Minar and the shock conquerer of Rafa Nadal at Wimbledon this year, Lukas Rosal, face newly-crowned ATP World Tour champions Marcel Granollers and Marc Lopez.
But captain Jaroslav Navratil is expected to bring in Berdych and Stepanek, who are 11-1 in Davis Cup doubles, depending on the events of Friday.
Sunday's reverse singles will see Berdych face Ferrer first and then Stepanek tackle Almagro.
Spain are going for their fourth Davis Cup crown in five years, but without the injured Rafa Nafal and the home comforts of Spanish clay, the match looks evenly poised.
The hosts have opted for hard indoor courts at Prague's O2 Arena, the same venue where the Czech women won the Federation Cup two weeks ago.
Victory by the men would be the first for the Czechs in the Davis Cup final since 1980 - when they won the title as Czechoslovakia.
It would also be the first time since the USA in 1990 that one nation has won the Federation Cup and Davis Cup in the same year.
Friday singles: R Stepanek (Cze) v D Ferrer (Esp), T Berdych (Cze) v N Almagro (Esp)
Saturday doubles: I Minar / L Rosol (Cze) v M Granollers / M Lopez (Esp)
Sunday: Reverse Singles T Berdych (Cze) v D Ferrer (Esp), R Stepanek (Cze) v N Almagro (Esp)