British number two Anne Keothavong's run at the Qatar Total Open came to an end with a 6-1 6-2 defeat by world number six Agnieszka Radwanska in the second round.
The Londoner, who appeared to be hampered by an arm problem, lost the first five games in each set to her Polish opponent in a one-sided contest.
But It has still been a positive week in Doha for Keothavong, who should climb up from her current ranking of 89th after beating compatriots Laura Robson and Heather Watson in qualifying and then seeing off top-50 player Tamira Paszek in round one.
Meanwhile, defending champion Vera Zvonareva of Russia limped out of the tournament with a left hip injury midway through her second round match against Romania's Monica Niculescu.
Niculescu had taken the first set 7-5 and was leading 3-2 in the second when sixth seed Zvonareva retired for the second successive week because of the same problem.
Last week in Pattaya, Zvonareva quit during her quarter-final match with another Romanian, Sorana Cirstea.
Earlier on Wednesday French fifth seed Marion Bartoli beat Spaniard Anabel Medina Garrigues 6-2 6-0 but Serbian former world number one Jelena jankovic bowed out, falling to Israeli Shahar Peer 7-6 (7-3) 6-2.
Caroline Wozniacki wasted three match points on her way to a 4-6 6-4 7-6 defeat by Lucie Safarova of the Czech Republic in her opening match.
Wozniacki, playing her first match since losing the world number ranking after the Australian Open, received a bye into the second round. She had all three match points in the 10th game of the third set.
"I am disappointed to have lost like this," said the Dane, the runner-up in Doha last year. "I had three match points but wasted them. I just want to move on from here."
Safarova won on her first match point to end the contest after nearly two hours. It was her second win over the Dane in three matches.
"I just kept fighting and I am so happy I didn't give up in the third set," Safarova said. "I turned the match around. It was amazing."
Safarova will meet Svetlana Kuznetsova in the third round on Thursday. The two-time Qatar finalist beat fellow Russian Maria Kirilenko 6-4 6-4.
New Australian Open champion Victoria Azarenka, in her first match as the new No. 1, dispatched Mona Barthel of Germany 6-1 6-0.