London Irish welcome back George Skivington and Blair Cowan for the visit of Newcastle Falcons on Saturday afternoon.
London Irish have signed English-born lock forward Matt Symons from Super Rugby side Waikato Chiefs.
Glasgow Warriors have signed Scotland international lock Kieran Low from London Irish.
Harlequins ended a five-game losing streak with a vital 26-20 win over London Irish at the Stoop on Saturday.
Harlequins will attempt to halt a three-game losing streak when they welcome London Irish to the Stoop on Saturday.
London Scottish have signed former England U20 international centre Guy Armitage on loan from London Irish.
An Alex Lewington hat-trick condemned London Welsh to a 16th successive defeat as London Irish triumphed 50-12.
Team news for Saturday's Aviva Premiership basement battle between London Welsh and London Irish.
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