Toulon were beaten at home by Stade Francais, while Racing Metro, Bayonne and Oyonnax all earned victories.
Champions Toulon, Brive, Clermont, Lyon, Grenoble and Stade Francais were all winners in the Top 14 on Saturday.
Alipate Ratini scored a magnificent hat-trick to lead Grenoble to a first win of the season, 37-23 over Bordeaux-Bègles.
Scotland scrum-half Mike Blair has confirmed he has joined French Pro2 club Brive from Edinburgh.
Scottish scrum-half Mike Blair has signed with Brive, according to various reports in the French press.
Toulouse finished the Top 14 regular season at the summit of the standings thanks to victory over Montpellier on Saturday.
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