Second takes on third in the pick of the Top 14 fixtures with Clermont set to entertain Toulouse on Saturday.
Clermont are unbeaten at home in 58 successive appearances - just one short of Stade Francais' record.
Former All Blacks fly-half Mike Delany should continue in the No 10 jersey after an impressive debut.
Toulouse are missing seven players, including injured Maxime Médard, Gary Botha, Timoci Matanavou, Patricio Albacete and Christopher Tolofua - however Luke McAlister and Louis Picamoles should be available.
League leaders Toulon face a much tougher encounter, with a trip to Grenoble.
With their Heineken Cup semi-final against Saracens coming up next week, Toulon have opted to rest a number of key players.
Jonny Wilkinson, Mathieu Bastareaud, Andrew Sheridan, Carl Hayman and Bakkies Botha are all missing, while Danie Rossouw and Maxime Mermoz are injury doubts.
Perpignan are the only side left with a chance of breaking into the play-off spots but must hit the road to already-relegated Agen.
Castres are chasing a home play-off and will hope for a full house of points when they welcome Mont-de-Marsan.
Montpellier face a tricky trip to Bayonne while Bordeaux-Bègles have nothing left to play for as they host a Biarritz side still harbouring hopes of qualifying for Europe's top division next term.