Clermont will look to carry their Heineken Cup form across to the Top 14 when they travel to Bordeaux on Friday.
Clermont toppled Leinster in back-to-back games to give the European hopes a massive boost but they will now look to close the gap on table-topping Toulon in the league.
Vern Cotter has made several changes to his line-up, though, with Benson Stanley, Regan King, David Skrela, Julian Malzieu, Elvis Vermeulen and Ti'i Paulo all called up.
Toulon will also look to maintain their impressive form - although Bakkies Botha will be missing from their line up for the clash with Agen.
Botha's absence is off-set by the return of Chris Masoe, while Jonny Wilkinson comes in for Frederic Michalak.
Agen, who beat Bucuresti 39-9 last time out, have bolstered their line-up with the loan signing of Ben Seymour.
While Clermont and Toulon return to domestic action in top form, Toulouse will be desperate to erase memories of their loss to the Ospreys when they travel to Grenoble.
Stade Francais will look to give themselves some breathing space when they tackle Biarritz, who will have Didier Faugeron and Laurent Rodriguez at the helm.
Bayonne are hot on the heels of the Parisians, though, and they will fancy their chances of victory against bottom club Mont de Marsan.
Racing Metro face a tough ask when they travel to fourth-placed Castres, while Perpignan will welcome Montpellier to the Stade Aime Giral.