Munster continue to set the pace at the top of the RaboDirect PRO12 standings as they prepare for a tricky away trip to Ospreys on Sunday.
The Munstermen have suffered just one defeat in the tournaments since round three but they will be wary of the Welshmen, having lost on their last three visits to Liberty Stadium.
Ospreys boss Steve Tandy has made four changes to his side. With Dan Biggar and Rhys Webb on international duty, there is a new half-back combination with Matthew Morgan and Tom Habberfield wearing the number 10 and nine jersies respectively.
The other changes are in the pack where Perry Parker comes in for Lloyd Peers in the second row, while Dan Suter makes his first PRO12 start at tighthead prop as a replacement for Aaron Jarvis.
Meanwhile, Donnacha Ryan, Tommy O'Donnell and Felix Jones all return from Ireland camp to start for Munster as Rob Penney makes six changes to the team that beat Zebre 36-8 last weekend.
Glasgow prop Mike Cusack will make his long-awaited return to action on Sunday after 14 months out through injury when the Warriors take on the Dragons at Rodney Parade.
The 29-year-old prop has been on the sidelines with a shoulder injury since December 2012, but returns to the Glasgow starting line-up for the trip to Newport.
NG Dragons have only recorded one victory in their last five PRO12 matches and Duncan Bell has returned until the end of the season, along with ex-Scotland international Bruce Douglas who is on loan from Bristol RFC.
Rhys Jones gets his second start of the season as one of six changes for the Dragons as he takes on the role of full-back.
Treviso, who have slipped to five straight defeats in all competitions, take on Ulster who have suffered just one defeat in their last ten fixtures.
Springbok Ruan Pienaar will start at fly-half for visitors Ulster and is partnered in the half-backs by Paul Marshall, who makes his first start since December.
Johann Muller captains the side from the second row where he is joined by Lewis Stevenson who has recovered from the neck injury that he sustained against Ospreys.
Robbie Diack, Sean Doyle and Roger Wilson are all named in the back-row, with Wilson set to make his 147th appearance for his Province.
Mat Berquist steps into the Treviso line-up at fly-half for James Ambrosini, while Brendan Williams shifts to full-back to accommodate Andrea Pratichetti on the left wing.
Connacht head into their clash having won all seven previous contests they have had with Zebre in all tournaments. Coach Pat Lam has made three changes to the team that beat Edinburgh.
Galway-born Darragh Leader, who made an appearance from the bench last weekend, is named at full-back for his fifth start of the season.
Dan Parks replaces an injured Craig Ronaldson and the former Scottish international is selected in an otherwise all-Irish qualified line-up.
The only change in the pack comes with the introduction of Academy forward Eoghan Masterson who slots into openside flanker to link up with Andrew Browne and John Muldoon in the back-row.
Ruggero Trevisan returns at full-back alongside Dion Berryman and Giovanbattista Venditti, with Troy Nathan and Brendon Leonard named as half-backs for Zebre.