Scrum-half Rhys Webb will make his 100th Ospreys appearance in Sunday's RaboDirect PRO12 clash with Treviso at Liberty Stadium.
Webb was one of six players who were released back to the Ospreys from the Wales Six nations squad and has gone straight back into the starting XV for this weekend's game.
He forms a half-back partnership with Wales team-mate Dan Biggar, while Ashley Beck is named at inside centre after also being released from national duty.
Up front, Ryan Bevington and James King come in at prop and lock respectively while the final player released from the Wales set-up, Dan Baker, is named on the bench.
The Ospreys currently lie fourth in the PRO12 table having not played at their usual home venue since their Heineken Cup defeat to Northampton on January 12.
"It's good to be heading back to the Liberty after five weeks away," head coach Steve Tandy said.
"There has been plenty to like about the performances in recent weeks, with a largely young group of players setting about the job in the absence of our international contingent.
"They've shown a good attitude, a desire to play in a positive way, and have shown an understanding of how we are trying to take our game."
Treviso, who earlier this week announced they would pull out of the competition at the end of the season, currently sit 10th in the table.
Ospreys: 15 Davies, 14 Hassler, 13 Spratt (c), 12 Beck, 11 Natoga, 10 Biggar, 9 Webb; 1 Bevington, 2 Baldwin, 3 Jarvis, 4 Peers, 5 King, 6 Ardron, 7 Lewis, 8 Bearman.
Replacements: 16 Dwyer, 17 Jones, 18 Suter, 19 Jones, 20 Baker, 21 Habberfield, 22 Morgan, 23 Dirksen.
Treviso: 15 Berquist, 14 Nitoglia, 13 Pratichetti, 12 Bacchin, 11 Williams, 10 Ambrosini, 9 Semenzato; 1 Muccignat, 2 Sbaraglini, 3 Fernandez-Rouyet, 4 Bernabo (c), 5 Van Zyl, 6 Loamanu, 7 Swanepoel, 8 Filippucci.
Replacements:16 Ceccato, 17 Acosta, 18 Di Santo, 19 Maistri, 20 Tveraga, 21 Sarto, 22 Menniti-Ippolito, 23 Di Bernardo.