The Friday night action sees in-form Leinster, having suffered just one defeat in their last eight matches, take on Newport Gwent Dragons in Dublin.
The Welsh side's only away victory in the tournament in almost twelve months came on a trip to Glasgow in November and they have won just one of their last four matches in the competition.
Leinster coach Matt O'Connor has mixed things up following last week's bonus-point victory away to Zebre with Ireland internationals Fergus McFadden, Martin Moore, Sean Cronin and Jack McGrath all cleared to play.
There are seven changes in total to the 15 that faced the Italians last weekend although Zane Kirchner continues at full-back.
In the back-row there is one change with Rhys Ruddock returning in a straight swap with Kevin McLaughlin.
Hallam Amos has made the move from wing to full-back from the game against Newcastle in the LV=Cup for Dragons.
He is joined in the back-three by Matthew Pewtner who returned from injury last week and Will Harries who moves from open side to blindside.
The centre pairing is made up of Pat Leach and experienced player Ashley Smith. Jason Tovey gets the nod as fly-half and welsh international Richie Rees takes his place as scrum half.
The front row takes on the form of Owen Evans as loose head prop, Welsh international hooker T Rhys Thomas is called upon and Nathan Buck comes in as tight head prop.
The second row is taken up by young gun Cory Hill and C Rob Sidoli, who also dons the captaincy. As for the back-row Lewis Evans and Nic Cudd are named as the flankers and Fijian international Netani Talei pulls on the number eight jersey.