Australia captain Stephen Moore has been ruled out for the rest of the season after suffering a serious knee injury against France.
Moore ruptured anterior cruciate and medial ligaments as he made a tackle in the first minute of Australia's crushing 50-23 victory, with scans later confirming he will need reconstructive surgery.
"The whole year is gone... he's obviously shattered," said Australia coach Ewen McKenzie.
"It leaves a bit of a void because we had put a lot of things in the pipeline."
The 31-year-old hooker was the Wallabies' third skipper in quick succession after James Horwill and Ben Mowen both saw their stints in the role come to an end.
Horwill lost the armband following concerns about his form on the tour of Europe last year, while Mowen was omitted from the squad after confirming plans to play overseas.
The captaincy is now likely to fall to either utility back Adam Ashley-Cooper or flanker Michael Hooper, who were jointly named as Moore's deputies last week.
Hooper, 22, led the side after Moore limped off and is favoured to take the reins for the rest of the series and season.
"He has a style about his captaincy that I respect," said McKenzie.
"It didn't affect his playing, he played exceptionally well and that's part of it too.
"I can't think of many players who play as consistently well as he does. I don't think I've seen him have an off day. He fronts up and is in every game.
"He's a 'lead-by-example' sort of guy and highly respected in the playing group - they're all good attributes."
The Australia captaincy has been something of a poisoned chalice in recent seasons, with 2012 seeing it change hands three times after Horwill, David Pocock and Will Genia all suffered injuries after being appointed.
Moore is likely to be replaced in the middle of the front row by Tatafu Polota-Nau, who came off the bench to good effect at Lang Park.
Meanwhile, lock Sam Carter - who made his Test debut against France - is also set to miss the rest of the series after suffering an ankle injury.
Carter was named man of the match, but McKenzie said the 24-year-old had played on despite sustaining the knock early on.
"He did it in the seventh minute, that really gives you an idea how tough the bloke is," said McKenzie.
"He showed great resilience and (the injury) didn't show up in his performance at all ... It was terrific courage."