Australia coach Ewen McKenzie has made four changes to his starting line-up for the Hopetoun Cup clash with Scotland at Murrayfield on Saturday.
The four changes are all in the backs with inside centre Mike Harris and outside centre Christian Leali'ifano teaming up in the midfield, while Joe Tomane and Chris Feauai-Sautia form a new pairing on the wings.
Leali'ifano and Tomane will be starting for the first time since they suffered injuries in Australia's record-breaking 54-17 victory over Argentina in October.
Feauai-Sautia will be winning his second cap for the Wallabies, while Harris, who has eight caps, gets his first opportunity in the team this year.
Harris and Leali'ifano replace Tevita Kuridrani, who has been been banned for five weeks for an illegal tackle during Sunday's 32-15 win over Ireland in Dublin, and Matt Toomua, who has a hamstring injury.
An additional four changes have been made to the bench with prop Ben Alexander, back-rower Ben McCalman and versatile backs Nick Phipps and Bernard Foley all coming into the squad.
Prop Paddy Ryan also features on the bench despite being one of six players suspended for one match for drinking in midweek ahead of the Ireland game.
Ryan will serve his ban in the game against Wales in a fortnight as IRB regulations state the 23-man squad must contain four props.
Adam Ashley-Cooper, Nick Cummins, Liam Gill, Tatafu Polota-Nau and Benn Robinson are all suspended for this match.
McKenzie said: "We've made some difficult selection decisions this week and now I'll be looking to see how those individuals with an opportunity respond to the challenge.
"All spring tour I've been impressed by the competition we've been able to create in a number of positions. Now, some of those guys get a chance to impress in new roles this week.
"Our main focus right now is to get our own backyard in order and start building momentum by winning consecutive games.
"We took a step forward last week by scoring our first back-to-back win of the year, but now it's about getting three in a row.
"However, Scotland is also a team that has gotten the better of Australia in the recent past and has won the past two games. This is an important match for the group to get right."
Australia: Folau, Tomane, Leali'ifano, Harris, Feauai-Sautia, Cooper, Genia, Mowen (capt), Hooper, Fardy, Horwill, Simmons, Kepu, Moore, Slipper.
Replacements: Fainga'a, Alexander, Ryan, Timani, McCalman, White, Phipps, Foley.