England will head to the Millennium Stadium on Saturday chasing a 13th Grand Slam crown - however it hasn't been all plain sailing in recent years.
It will be the 19th time England have reached the last weekend of the Five/Six Nations with a chance of completing a clean sweep - but on six occasions, all of which have been away, they have ended up missing out.
And ahead of the mouth-watering clash against a resurgent Wales, Sky Sports looks back at five failures that remain fresh in the memory...
Murrayfield 1990 - Scotland 13 England 7
Arguably the most famous of England's Grand Slam 'chokes'. Will Carling's men had brushed aside France, Ireland and Wales en route to the Murrayfield showdown - scoring 11 tries and conceding just two. Accusations of English arrogance added fuel to the fire, while captain David Sole provided the spark with his slow walk out. With Flower of Scotland belting out around Murrayfield and the home pack causing carnage across the pitch, England were stunned. The decisive moment, though, came as Gavin Hastings kicked ahead and Tony Stanger outpaced Rory Underwood to clinch the Grand Slam for Scotland.
Wembley 1999 - Wales 32 England 31
It was the one that got away for England. They had played brilliant running rugby in the first half at Wembley with Matt Perry, Steve Hanley and Richard Hill all crossing. The boot of Neil Jenkins and a try from Shane Howarth had kept Wales in the match, but entering the final minutes England had led by six points. That was until Scott Gibbs scored one of the most memorable tries in the championship - the powerhouse centre taking the ball at pace before dancing his way past the England defence to dive over. Jenkins slotted over the conversion to complete the win.
Murrayfield 2000 - Scotland 19 England 13
Still stinging from their loss to Wales in the final fixture the previous year, surely England couldn't mess it up again? However they did as Scotland spoilt the party once again. This time Scotland had been on course for the wooden spoon but they rose to the occasion in atrocious conditions at Murrayfield. Duncan Hodge earned his place in Scottish folklore with all 19 points as England were left devastated.
Lansdowne Road 2001 - Ireland 20 England 14
England completed an unwanted hat-trick in 2001 as they this time saw Ireland end their Grand Slam hopes. In a match held back until October due to the foot and mouth crisis, England failed to match their form from the wins over Wales, Italy, France and Scotland earlier in the year. From the moment Keith Wood surged over in the 15th minute, Ireland never looked back. England had their chances with Peter Stringer saving the day with his tap-tackle on Dan Luger.
Aviva Stadium 2011 - Ireland 24 England 8
A decade on from their heroics in Dublin, Ireland once again proved to be England's nemesis. Martin Johnson's side were simply no match for a rampant Irish, with England left shell-shocked by the first-half onslaught. Tommy Bowe and Brian O'Driscoll scored tries, while Jonathan Sexton add 14 points from the boot to put the hosts 24-3 up after 48 minutes. Steve Thompson scored a rare interception try soon after but there was to be no sensational comeback as the Ireland defence kept England at bay.
Will England win the Grand Slam in Cardiff?