Leicester Tigers have recalled Sam Harrison and Owen Williams for Friday's LV= Cup match against Bath at Welford Road.
Despite last week's defeat away at Harlequins, Leicester still have a chance of making it through to the semi-finals from Pool 2, which is the only one of the four still to be decided.
Leicester trail Sale - who travel to the Ospreys on the same night - by one point and are level with Exeter, whose final pool match is away at Worcester on Saturday.
Harrison has recovered from injury to make his fourth appearance of the season, taking over from David Mele, while fly-half Williams exchanges places with Ryan Lamb who is among the replacements.
George Catchpole is selected on the left wing following Adam Thompstone's call-up to the England Saxons squad.
Tom Price comes in at lock, with Steve Mafi switching to the back row alongside Argentina international Pablo Matera, who makes his first appearance at Welford Road, and No 8 Thomas Waldrom, who is named as captain.
Bath have already won Pool 3 and hand a first start to flanker David Sisi on the blindside.
Academy prospect Ollie Devoto is given the nod at fly-half with the experienced Peter Stringer joining him in the half-backs.
Stuart Hooper returns at lock to captain the side, alongside Dominic Day andl in the front-row, Charlie Beech gets his first start of the season at loosehead.
Academy back Ollie Devoto is given the nod at fly-half with the experienced Peter Stringer joining him in the halfbacks.
The back division sees only two changes from those on duty for the win against Cardiff Blues last weekend; Gavin Henson is named at inside centre and Nick Abendanon returns at full-back.
Sale will make the semi-finals with a bonus-point win at the Ospreys and have made just one tweak to their starting XV, Jonathan Mills in for Kirill Kulemin at lock.
The Ospreys have lost all three of their games in the competition and have made seven changes from the side beaten by Exeter last week, including Sam Davies at fly-half.
Also on Friday, Samoa international Isaia Tuifua will make his debut off the bench for Cardiff Blues in their meeting with Harlequins at the Arms Park.
And Argentina international Gonzalo Tiesi has been named in Newcastle Falcons' starting XV for the first time after recovering from a hamstring injury. The Falcons are at home to Newport Gwent Dragons with both teams already eliminated.