Aviva Premiership leaders Saracens host Leicester Tigers on Saturday aiming to make it eight wins on the bounce in all tournaments.
Saracens' David Strettle is replaced by Jack Wilson on the wing, Alex Goode comes back at full-back in the place of Ben Ransom, while Duncan Taylor misses out with an ankle complaint and is replaced by Chris Wyles at inside centre.
Scrum-half Richard Wigglesworth is partnered by Owen Farrell at outside half. Up front, Richard Barrington starts at loosehead prop - with Mako Vunipola on the bench - and Matt Stevens returns at tighthead prop.
Steve Borthwick captains the side at lock, and is joined by South African international Alastair Hargreaves in the second row. In the back-row, Scotland captain Kelly Brown starts at openside flanker, with Billy Vunipola at blindside and Ernst Joubert at number eight.
Mathew Tait returns to the Leicester Tigers line-up, taking the number 15 shirt for the first time this season following an ankle injury.
Matt Smith comes in at centre and Ryan Lamb starts at fly-half. Changes in the forwards include the return of Boris Stankovich to the front row and Ed Salter at lock while flanker Pablo Matera gains a first start. Terrence Hepetema returns from injury to claim a place among the replacements.
Third-placed Bath host fourth-placed Harlequins at The Rec looking to maintain a ten match winning run.
The hosts have made seven changes to their starting line-up. In the pack, Rob Webber and Anthony Perenise form the front row with Paul James, with Dave Attwood coming back to partner captain Stuart Hooper in the engine room. Carl Fearns shifts to number eight as Francois Louw takes the openside shirt and Matt Garvey continues on the blindside.
George Ford is joined in the half-backs by Peter Stringer. Out wide, Horacio Agulla is selected on the right wing and Matt Banahan continues on the left. Jonathan Joseph combines with Kyle Eastmond in the midfield, and Anthony Watson completes the line-up at full-back.
The visitors, who have won their last four games, have made just two changes to their starting line-up. Paul Doran Jones and Karl Dickson start at tighthead prop and scrum-half in place of Will Collier and Danny Care who picked up knocks last week.
Among replacements is Max Crumpton, who has arrived from Saracens due to injury to three of the four hookers at Quins. Tom Guest returns from injury and is joined by Sam Stuart.
In other action, second-placed Northampton Saints head to London Wasps having made three straight swaps between the bench and their starting 15, with Kahn Fotuali'i, Mike Haywood and Sam Dickinson coming in for Lee Dickson, Dylan Hartley and Courtney Lawes respectively.
Ashley Johnson returns to Wasps' starting line-up. He is joined in the back-row by Sam Jones at number eight and James Haskell on the openside. In front of them is Tom Palmer and Joe Launchbury while the front row is made up of Matt Mullan, Carlo Festuccia and Jake Cooper-Woolley.
In the backs Charlie Davies and Andy Goode return to fitness and start at nine and ten, while Charlie Hayter and Chris Bell partner in midfield. The back three sees Tom Varndell start, with Will Helu on the other wing and Elliot Daly at full-back.
Exeter Chiefs host Newcastle at Sandy Park hoping to end a five-game losing streak.
Damian Welch, Ben White and Kai Horstmann all return in the pack for the hosts, Gareth Steenson is back at fly-half while Sam Hill comes into the centre at the expense of the injured Phil Dollman.
Newcastle welcome back experienced scrum-half Mike Blair, one of six changes.
Danny Barnes partners Adam Powell at the heart of the back-line, while Ryan Shortland gets the nod on the wing. Kieran Brookes comes in at tighthead, Carlo del Fava replaces Sean Tomes in the second-row and stand in skipper Ally Hogg rounds off the changes at number eight.