Sale expect to be without Lionel Faure for a prolonged spell after he sustained a suspected broken leg during their EDF Cup win over Newcastle.
The French prop suffered the injury in a heavy challenge shortly before half time and was taken from the pitch on a stretcher.
He was rushed straight to hospital where the Sharks expect the break to be confirmed.
"It's a serious blow for Lionel and for the team," admitted director of rugby Philippe Saint-Andre.
"It was a bad injury and we think he's broken a bone in his leg. He's gone straight to hospital and we'll await the results of the tests.
"It's very disappointing because Jon Bryant also picked up a calf injury and could be out for a while."
Sale were comfortable winners at Edgeley Park thanks to two tries from Oriol Ripol and a third from Chris Jones.