Queensland wing Chris Feauai-Sautia is facing at least six months out with injury as the Reds' injury problems mount.
Feauai-Sautia dislocated his shoulder while diving to try to stop a Blues try late in the first half of last Friday's Super 15 match.
He will be out for the remainder of the season, after Reds medical staff opted for surgery to fix the injury.
Reds head coach Richard Graham said: "Chris dislocated his shoulder when diving for a ball. The scans revealed a tear and the medical team believe the best course of action is a complete reconstruction. This means he will be unavailable for at least six months."
There were further casualties from the 44-14 defeat last Friday. Liam Gill, who had just returned from a five-week layoff due to a hamstring injury, strained his calf during the Blues match and is expected to be out for two weeks.
And Eddie Quirk will be out for two weeks after suffering a rib injury during the match.
Graham was disappointed to lose three players at such an important juncture in the team's season.
"It is disappointing to lose the three boys," said Graham.
"Eddie (Quirk) has started every game this season and had been very good at the tackle and the contest.
"Liam had just returned from a five-week layoff with a hamstring injury and I thought he was very good in the 50 minutes he played last weekend.
"We are fortunate that both Beau (Robinson) and Curtis (Browning) have been involved every week in the match squad. We also have Simmo (Rob Simmons) and Dave McDuling who can play at blindside flanker.
The Reds rehab team now features eight players, with the new additions joined by Lachie Turner (ankle-return Round 16), Aidan Toua (pectoral-return Round 17) and Chris Kuridrani (ankle-return Round 16).
In some good news for the Reds, winger Dom Shipperley is available for selection after recovering from a hip injury suffered against the Stormers in Round 7.