Australia captain James Horwill looks set to miss the rest of the season with a serious hamstring injury.
The Reds second row has been sidelined since tearing his right hamstring during the victory over the Brumbies in May.
And Wallabies coach Robbie Deans has conceded that Horwill will not be playing any time soon.
"It does look like he's got a long-injury," Deans told ABC radio on Friday.
"It's unlikely he'll play any rugby this year."
With Horwill out, flanker David Pocock had taken over the captaincy - however Deans has refused to comment on who will step up to the role after the series against Wales.
"There's just no point in looking beyond each week," said Deans. "None of us know what's coming in the future.
"Clearly David's done a great job. He's responded to the challenge and it came around quickly."