Leicester have the chance to move up to third in the Aviva Premiership table - for a few hours at least - when they travel to rock-bottom Worcester on Friday.
The Tigers currently sit in fifth place but could leapfrog both Bath and Harlequins, who play home games on Saturday and Sunday respectively.
Ben Youngs and Ed Slater both return from England's Six Nations squad to start for the visitors at Sixways, while Toby Flood captains Leicester from fly-half.
Adam Thompstone is ruled out after taking a knock on his England Saxons debut against Scotland 'A', but Mathew Tait is among the senior players back in action after sitting out the recent rounds of the LV= Cup.
Worcester, meanwhile, are set to welcome back Agustin Creevy as they desperately go in search of a win to keep their hopes alive of avoiding finishing at the foot of the standings.
The Argentina international, who made a try-scoring debut for the club last October, has been sidelined for the past three months with a knee injury.
Jonny Arr returns at scrum-half, Paul Warwick replaces Ignacio Mieres at fly-half and Alex Grove slots in at outside centre after playing for Scotland's second string last Friday.
"They've got a significant injury list but they have a significant squad," said Warriors director of rugby Dean Ryan. "That's what a good club is. It has layers of depth and a heritage of success."
The other top-flight fixture to take place on the same night sees Sale host Gloucester at the AJ Bell Stadium.
The Sharks have recalled Dwayne Peel and Danny Cipriani as their half-back combination as they make wholesale changes from the line-up that took the field against Ospreys last time out in cup action.
As for the visitors, James Hudson will captain the Cherry and Whites for the first time.
They are able to welcome back Freddie Burns from Saxons duty, with Jimmy Cowan selected alongside him in the half-back roles. Ryan Mills shifts from the number 10 position to inside centre to make way for Burns.
Gloucester will be eager to avenge the defeat they suffered at Kingsholm against the same opponents but travel north having won just twice in their last 10 league outings.