Wasps winger Christian Wade could be out for up to six months after injuring his foot during last weekend's 19-12 win at London Irish.
In a statement, the London club revealed that the 22-year-old is set to have surgery to repair significant ligament damage.
It is a blow for both the club and Wade's country, England, who Wade had been hoping to represent at the Six Nations in early 2014.
Director of rugby Dai Young said: "It is devastating news for both the player and the club.
"Christian was hugely unlucky to miss out on being capped this Autumn with England and he had hoped to push on and put in some good performances for Wasps to get him in contention for Six Nations selection.
"It is a huge blow for him but he is a young player with a huge future and his time will come around again."
Tom Varndell returned to training this week following injury and could fill the void left by Wade.