Juan Pablo Orlandi makes his full debut for Bath at the Recreation Ground on Sunday as they welcome Exeter Chiefs for a West Country derby.
Bath are further bolstered further by the release of England trio Dave Attwood, Anthony Watson and Rob Webber, who all make the starting line-up.
Martin Roberts and George Ford combine in the half-backs to control proceedings, with the powerful Matt Banahan and fleet-footed Anthony Watson on either wing.
Exeter have not tasted victory at The Rec since 1978. After getting their campaign in the competition underway with a win last week, the visitors make seven changes with James Phillips handed his first start of the season at No.8.
Behind them, Haydn Thomas and Henry Slade form a new half-back partnership, whilst the experienced Jason Shoemark not only returns to the midfield, but also skippers the side with Ceri Sweeney dropping down to the bench.
Kieran Low returns to the London Irish back row when they host Northampton Saints at the Madejski Stadium on Sunday.
Brian Smith, Exiles Director of Rugby said: "We have made a couple of changes to the squad from last week to freshen things up a little, but on the whole, several of the boys that played last week have a second chance to impress against a good Northampton side."
For their part, Northampton have handed full debuts to Academy produced duo Alex Day and Ethan Waller.
Elsewhere, Tom Collins returns to the wing with Ken Pisi on Samoa duty as the Saints go looking for a second win at the home of the Exiles in a fortnight after a 19-16 Premiership triumph earlier this month.
Saracens have named Charlie Hodgson at fly-half in their side for Sunday's clash with the Scarlets.
The 33-year-old lines up alongside Ben Spencer in the halves, whilst young centres Nick Tompkins, 18, and Tim Streather, 25, make their home debuts for the club.
In the pack, Jared Saunders moves from hooker to loosehead prop, with Jamie George wearing the number 2 shirt. Alastair Hargreaves replaces George Kruis, to partner Mouritz Botha in the second row and Jacques Burger returns at openside flanker, with Matt Hankin chosen at blindside - Jackson Wray retains the number eight shirt to complete the back row.