Owen Farrell returns to the Saracens side at inside centre for Saturday's clash with Sale Sharks and will partner Chris Wyles in the midfield.
Elsewhere, Jack Wilson makes his Premiership debut on the right wing, while Steve Borthwick - who this week announced he is to retire at the end of the season - captains the side at second row.
For Sale, Charlie Ingall starts on the right wing with Danny Cipriani partnering Dwayne Peel at half-back.
Argentina's Horacio Agulla and South African Francois Louw return to the Bath starting line-up for the clash with Exeter following international commitments.
Meanwhile, Chiefs boss Baxter has tinkered with his formation offering a first league start of the season to Luke Arscott at full-back. His inclusion means Phil Dollman drops back into the midfield where he will partner the recalled Jason Shoemark.
Up front, the only change to the Exeter pack sees Ben Moon come in at loosehead for Brett Sturgess, who drops to the bench alongside Ian Whitten.
Worcester Warriors flanker Richard de Carpentier will get his second Premiership start of the season against Northampton at Sixways, lining up alongside Sam Betty and captain Jonathan Thomas in the back-row.
Argentinean second row Mariano Galarza returns after international duty and Paul Hodgson and Josh Matavesi are also restored to the starting line-up, while Max Stelling could be in line for his first-ever Aviva Premiership appearance after being named amongst the replacements.
Northampton have made five changes to the side that beat Newcastle Falcons last weekend.
Fit-again Dylan Hartley and flanker Tom Wood are back after England's autumn internationals, while England Under-20s' Junior World Championship winner Tom Stephenson is primed for a Premiership debut from the bench.
London Irish stalwart Topsy Ojo will make his 200th appearance for the Exiles against London Wasps at the Madejski Stadium. The winger, who signed a new three-year deal earlier in the week, will be joined in the back three by Alex Lewington and James O'Connor.
In the pack, John Yapp, Jimmy Stevens and Leo Halavatau will start in the front row with Ian Gough and George Skivington in the second row and Blair Cowan, Jebb Sinclair and Chris Hala'ufia behind them.
London Wasps boss Dai Young has made eight changes to his starting XV with Christian Wade returning to the side and Tongan Will Helu making his first Premiership start on the other wing.
Jake Cooper-Woolley comes back into the side to replace Phil Swainston in the front row and is joined there by Carlo Festuccia and Matt Mullan.