Former Scotland centre Joe Ansbro has been forced to retire having failed to overcome a neck injury.
The 27-year-old suffered a triple fracture of his C1 vertebrae in a pre-season friendly against Munster in August 2012 and has had to call time on a promising career.
Ansbro, who joined London Irish in 2011 having impressed at Northampton, said: "It's with great sadness that I announce my retirement from professional rugby.
"I've been fortunate enough to play top-level rugby for both Northampton Saints and London Irish. To gain international recognition with Scotland has been an immense honour; victories over South Africa and Australia stand out.
"Playing this great game at the highest level is a privilege and I will always look back on my career with fond memories.
"Thank you also to all the supporters, players, coaches and staff at Scottish Rugby for making the responsibility of representing Scotland such an enjoyable experience.
"I'd especially like to thank James Peckitt (London Irish physiotherapist) and doctor James Robson for helping me through a difficult rehabilitation process.
"Finally, thank you to my family, friends and agent for their continuing support and positive influence."
Ansbro - a Cambridge University graduate - represented Scotland 11 times and scored three tries having made his debut in 2009.